The Getty Center at the Westside has been the site of the fabulous art collection of the Getty family patriarch since 1997. After having been housed in the Getty Villa for decades, this priceless collection was moved to its present location and been put on public display. The Center itself is a notable attraction in its own right, featuring white metal pavilions that contain exquisite French furniture, some legendary Impressionist pieces, and a variety of exhibitions. Although it can be quite a challenge to get there due to its inaccessible location, a visit to the Getty Center will definitely be worth the trip.
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With so many things going in LA at night, you would have hopefully saved some of your energy or gone back to your hotel for a quick nap before heading out. In any case, there are literally hundreds of nightspots and various other attractions for you and your escort to enjoy, so take your pick!
N2 - Dupilumab, a fully human monoclonal antibody against Interleukin-4 receptor α is approved as add-on maintenance treatment for inadequately controlled type 2 severe asthma. This systematic review evaluates the effectiveness, safety and economic impact of dupilumab compared to standard of care for uncontrolled severe asthma.Pubmed, EMBASE and Cochrane Library were searched for RCTs and health economic evaluations. Critical and important asthma-related outcomes were evaluated. The risk of bias and the certainty of the evidence were assessed using GRADE.Three RCTs including 2735 subjects > 12 years old and 24 to 52 weeks of follow-up were included. Dupilumab reduced with high certainty severe asthma exacerbations (RR 0.51; 95%CI 0.45 to 0.59) and oral corticosteroid use (mean difference (MD) -28.2 mg/day; 95% CI -40.7 to -15.7). Asthma control (ACQ-5), quality of life (AQLQ) and rescue medication use [puffs/day] improved, without reaching the minimal important clinical difference: ACQ-5 MD -0.28 (95%CI -0.39 to -0.17); AQLQ MD +0.28 (95% CI 0.20 - 0.37); rescue medication MD -0.35 (95%CI -0.73 to +0.02). FEV1 increases (MD +0.15; 95% CI +0.11 to +0.18) (moderate certainty). There is increased rate of dupilumab-related adverse events (AEs) (moderate certainty) and of drug-related serious AEs (low certainty). The incremental cost-effectiveness ratio versus standard therapy was 464,000 $/QALY (moderate certainty).More data on long term safety are needed both for children and adults, together with more efficacy data in the paediatric population.
AB - Dupilumab, a fully human monoclonal antibody against Interleukin-4 receptor α is approved as add-on maintenance treatment for inadequately controlled type 2 severe asthma. This systematic review evaluates the effectiveness, safety and economic impact of dupilumab compared to standard of care for uncontrolled severe asthma.Pubmed, EMBASE and Cochrane Library were searched for RCTs and health economic evaluations. Critical and important asthma-related outcomes were evaluated. The risk of bias and the certainty of the evidence were assessed using GRADE.Three RCTs including 2735 subjects > 12 years old and 24 to 52 weeks of follow-up were included. Dupilumab reduced with high certainty severe asthma exacerbations (RR 0.51; 95%CI 0.45 to 0.59) and oral corticosteroid use (mean difference (MD) -28.2 mg/day; 95% CI -40.7 to -15.7). Asthma control (ACQ-5), quality of life (AQLQ) and rescue medication use [puffs/day] improved, without reaching the minimal important clinical difference: ACQ-5 MD -0.28 (95%CI -0.39 to -0.17); AQLQ MD +0.28 (95% CI 0.20 - 0.37); rescue medication MD -0.35 (95%CI -0.73 to +0.02). FEV1 increases (MD +0.15; 95% CI +0.11 to +0.18) (moderate certainty). There is increased rate of dupilumab-related adverse events (AEs) (moderate certainty) and of drug-related serious AEs (low certainty). The incremental cost-effectiveness ratio versus standard therapy was 464,000 $/QALY (moderate certainty).More data on long term safety are needed both for children and adults, together with more efficacy data in the paediatric population.
We initiated this study to document the overall incidence of TMDsin patients with dentoskeletal deformities who were scheduled to undergoorthognathic surgery. The motivation for such documentation was to ascertainwhether surgery could prove useful in the improvement or eradication of TMDs,in addition to correcting the structural deformities, as some data suggest.[sup][21],[22],[23],[24] Our systematic collection of pre and postoperativedata enabled us to make a proper evaluation of the possiblebenefits/detrimental effects of surgery on TMDs on this patient population. 2ff7e9595c
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